Publications

2008

Zhou, A.; Hanson, P. R. Synthesis of Sultam Scaffolds via Intramolecular Oxa-Michael and Diastereoselective Baylis-Hillman Reactions. Org. Lett. Web Release Date: 14-Jun-2008; ASAP Article. Click here for online access to article.

Shi, F.; Waldo, J. P.; Chen, Y.; Larock, R. C. Benzyne Click Chemistry: Synthesis of Benzotriazoles from Benzynes and Azides. Org. Lett. 2008, 10(12), 2409–2412. Click here for online access to article.

Stoianova, D. S.; Yao, L.; Rolfe, A.; Samarakoon, T.; Hanson, P. R. High-load, oligomeric monoamine hydrochloride: facile generation via ROM polymerization and application as an electrophile scavenger. Tetrahedron Lett. 2008, 49(29-30), 4553-4555. Click here for online access to article.

Jiménez-Hopkins, M.; Hanson, P. R. An RCM Strategy to Stereodiverse δ-Sultam Scaffolds. Org. Lett. 2008, 10(11), 2223–2226. Click here for online access to article.

Frankowski, K. J.; Golden, J. E.; Zeng, Y.; Lei, Y.; Aubé, J. Syntheses of the Stemona Alkaloids (±)-Stenine, (±)-Neostenine, and (±)-13-Epineostenine Using a Stereodivergent Diels-Alder/Azido-Schmidt Reaction. J. Am. Chem. Soc. 2008, 130(18), 6018-6024. Click here for online access to article.

Stensrud, K. F., Heger, D., Šebej, P., Wirz, J., Givens, R. S. Fluorinated photoremovable protecting groups: The influence of fluoro substituents on the photo-Favorskii rearrangement. Photochem. Photobiol. Sci. 2008, 7(5), 614-624. Click here for online access to article.

Nöth, J.; Frankowski, K. J.; Neuenswander, B.; Aubé, J.; Reiser, O. Efficient Synthesis of γ-Lactams by a Tandem Reductive Amination/Lactamization Sequence. J. Comb. Chem. 2008, 10(3), 456–459. Click here for online access to article.

Poon, K. W. C.; Liang, N.; Datta, A. De Novo Synthetic Route to a Combinatorial Library of Peptidyl Nucleosides. Nucleosides, Nucleotides Nucleic Acids 2008, 27(4), 389-407. Click here for online access to article.

Just, Z. W.; Larock, R. C. Synthesis of 2(3H)-Furanones via Electrophilic Cyclization. J. Org. Chem. 2008, 73(7), 2662-2667. Click here for online access to article.

Ge, H.; Niphakis, M. J.; Georg, G. I. Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates. J. Am. Chem. Soc. 2008, 130(12), 3708-3709. Click here for online access to article.

Theertham, B.; Wang, J. L.; Fang, J.; Lushington, G. H. Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics. Curr. Comput.-Aided Drug Des. 2008, 4(1), 23-34. Click here for online access to article.

Givens, R. S.; Heger, D.; Hellrung, B.; Kamdzhilov, Y.; Mac, M.; Conrad, P. G., II; Cope, E.; Lee, J. I.; Mata-Segreda, J. F.; Schowen, R. L.; Wirz, J. The Photo-Favorskii Reaction of p-Hydroxyphenacyl Compounds is Initiated by Water-Assisted, Adiabatic Extrusion of a Triplet Biradical. J. Am. Chem. Soc. 2008, 130(11), 3307-3309. Click here for online access to article.

Zhang, L.; Lushington, G. H.; Neuenswander, B.; Hershberger, J. C.; Malinakova, H. C. Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone Libraries via Tactical Combination of Cu-Catalyzed Three-Component Coupling and Diels-Alder Reactions. J. Comb. Chem. 2008, 10(2), 285-302. Click here for online access to article.

Fenster, E.; Rayabarapu, D. K.; Zhang, M.; Mukherjee, M.; Hill, D.; Neuenswander, B.; Schoenen, F.; Hanson, P. R.; Aubé, J. Three-Component Synthesis of 1,4-Diazepin-5-ones and the Construction of γ-Turn-like Peptidomimetic Libraries. J. Comb. Chem. 2008, 10(2), 230-234. Click here for online access to article.

Vedantham, P., Zhang, M., Gor, P. J., Huang, M., Georg, G. I., Lushington, G. H., Mitscher, L. A., Ye, Q.-Z., Hanson, P. R. Studies Towards Synthesis of Methionine Aminopeptidase Inhibitors: Diversification Utilizing a ROMP-Derived Coupling Reagent. J. Comb. Chem. 2008, 10(2), 195-203. Click here for online access to article.

Vedantham, P.; Guerra, J. M.; Schoenen, F.; Huang, M.; Gor, P. J.; Georg, G. I.; Wang, J. L.; Neuenswander, B.; Lushington, G. H.; Mitscher, L. A.; Ye, Q.-Z.; Hanson, P. R. Ionic Immobilization, Diversification and Release: Application to the Generation of a Library of Methionine Aminopeptidase Inhibitors. J. Comb. Chem. 2008, 10(2), 185-194. Click here for online access to article.

Smalter, A., Huan, J., Lushington, G. Structure-based Pattern Mining For Chemical Compound Classification. Series on Advances in Bioinformatics and Computational Biology: Proceedings of the 6th Asia Pacific Bioinformatics Conference (APBC) 2008, 6, 39-48.

Li, K.; Tunge, J. A. Chemical Libraries via Sequential C-H Functionalization of Phenols. J. Comb. Chem. 2008, 10(2), 170-174. Click here for online access to article.

Poon, K. W. C.; Lovell, K. M.; Dresner, K. N.; Datta, A. Trimethylsilyl trifluoromethanesulfonate (TMSOTf) assisted facile deprotection of N,O-acetonides. J. Org. Chem. 2008, 73(2), 752-755. Click here for online access to article.

Liu, Z.; Shi, F.; Martinez, P. D. G.; Raminelli, C.; Larock, R. C. Synthesis of Indazoles by the [3+2] Cycloaddition of Diazo Compounds with Arynes and Subsequent Acyl Migration. J. Org. Chem. 2008, 73(1), 219-226. Click here for online access to article.

Fenster, E., Smith, B. T., Gracias, V., Milligan, G. L., and Aubé, J. Nucleophilic Addition to Iminium Ethers in the Preparation of Functionalized N-Alkyl Heterocycles. J. Org. Chem. 2008, 73(1), 201-205. Click here for online access to article.

2007

Wang, Xin; Turunen, B. J.; Leighty, M. W.; Georg, G. I. Microwave-assisted Suzuki–Miyaura couplings on α-iodoenaminones. Tetrahedron Lett. 2007, 48(50), 8811-8814. Click here for online access to article.

Waldo, J. P.; Larock, R. C. The Synthesis of Highly Substituted Isoxazoles by Electrophilic Cyclization: An Efficient Synthesis of Valdecoxib. J. Org. Chem. 2007, 72(25), 9643-9647. Click here for online access to article.

Frankowski, K. J.; Hirt, E. E.; Zeng, Y.; Neuenswander, B.; Fowler, D.; Schoenen, F.; Aubé, J. Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels–Alder/Acylation Sequence. J. Comb. Chem. 2007, 9(6), 1188–1192. Click here for online access to article.

Buszek, K. R.; Luo, D.; Kondrashov, M.; Brown, N.; VanderVelde, D. Indole-Derived Arynes and Their Diels-Alder Reactivity with Furans. Org. Lett. 2007, 9(21), 4135 -4137. Click here for online access to article.

Chaudhry, P.; Schoenen, F.; Neuenswander, B.; Lushington, G. H.; Aubé, J. One-Step Synthesis of Oxazoline and Dihydrooxazine Libraries. J. Comb. Chem. 2007, 9(3), 473 - 476. Click here for online access to article.

Huang, Y–T.; Blagg, B. S. J. A Library of Noviosylated Coumarin Analogues. J. Org. Chem. 2007, 72(10), 3609 - 3613. Click here for online access to article.

Zhang, M.; Flynn, D. L.; Hanson, P. R. Oligomeric Benzylsulfonium Salts: Facile Benzylation via High-Load ROMP Reagents. J. Org. Chem. 2007, 72(9), 3194-3198. Click here for online access to article.

Buszek, K.R.; Brown, N. Improved Method for the Diimide Reduction of Multiple Bonds on Solid-Supported Substrates. J. Org. Chem. 2007, 72(8), 3125 - 3128. Click here for online access to article.

Buszek, K. R.; Brown, N. N-Vinylpyridinium and -ammonium Tetrafluoroborate Salts: New Electrophilic Coupling Partners for Pd(0)-Catalyzed Suzuki Cross-Coupling Reactions. Org. Lett. 2007, 9(4), 707 - 710. Click here for online access to article.

Liu, Z.; Larock, R. C. Palladium-Catalyzed, Sequential, Three-Component Cross-Coupling of Aryl Halides, Alkynes, and Arynes. Angew. Chem., Int. Ed. 2007, 46(14), 2535 - 2538. Click here for online access to article.

Zhang, L.; Malinakova, H. C. Copper-Catalyzed Multicomponent Cascade Process for the Synthesis of Hexahydro-1H-isoindolones. J. Org. Chem. 2007, 72(4), 1484 - 1487. Click here for online access to article.

Worlikar, S. A.; Kesharwani, T.; Yao, T.; Larock, R. C. Synthesis of 3,4-Disubstituted 2H-Benzopyrans through C-C Bond Formation via Electrophilic Cyclization. J. Org. Chem. 2007, 72(4), 1347 - 1353. Click here for online access to article.

Zhao, J.; Larock, R. C. Synthesis of Xanthones, Thioxanthones, and Acridones by the Coupling of Arynes and Substituted Benzoates. J. Org. Chem. 2007, 72(2), 583 - 588. Click here for online access to article.

Liu, Z.; Larock, R. C. Synthesis of carbazoles and dibenzofurans via cross-coupling of o-iodoanilines and o-iodophenols with silylaryl triflates and subsequent Pd-catalyzed cyclization. Tetrahedron 2007, 63(2), 347-355. Click here for online access to article.

Manyem, S.; Sibi, M. P.; Lushington, G. H.; Neuenswander, B.; Schoenen, F.; Aubé, J. Solution-Phase Parallel Synthesis of a Library of Δ²-Pyrazolines. J. Comb. Chem. 2007, 9(1), 20-28. Click here for online access to article.

Liu, Z.; Larock, R. C. Highly Efficient Route to Fused Polycyclic Aromatics via Palladium-Catalyzed Aryne Annulation by Aryl Halides. J. Org. Chem. 2007, 72(1), 223 - 232. Click here for online access to article.

2006

Laursen, J. B.; Nielsen, J.; Haack, T.; Pusuluri, S.; David, S.; Balakrishna, R.; Zeng, Y.; Ma, Z.; Doyle, T. B.; Mitscher, L. A. Further Exploration of Antimicrobial Ketodihydronicotinic Acid Derivatives by Multiple Parallel Syntheses. Comb. Chem. High Throughput Screening 2006, 9(9), 663-681. Click here for online access to article.

Ward, T. R.; Georg, G. I. N,O-Dimethylhydroxylamine. Fuchs, P. L. Ed.; In Electronic Encyclopedia of Reagents in Organic Synthesis (e-EROS). Wiley, Chichester 2006.

Chaudhury, S.; Welch, T. R.; Blagg, B. S. J. Hsp90 as a Target for Drug Development. ChemMedChem 2006, 1(12), 1331-1340. Click here for online access to article.

Li, K.; Vanka, K.; Thompson, W. H.; Tunge, J. A. Stereochemical Control in the Reduction of 2-Chromanols. Org. Lett. 2006, 8(21), 4711-4714. Click here for online access to article.

Herpel, R. H.; Vedantham, P.; Flynn, D. L.; Hanson, P. R. High-Load, Oligomeric Phosphonyl Dichloride: Facile Generation via ROM Polymerization and Application to Scavenging Amines. Tetrahedron Lett. 2006, 47(36), 6429-6432. Click here for online access to article.

Turunen, B. J.; Georg, G. I. Amino Acid-Derived Enaminones: A Study in Ring Formation Providing Valuable Asymmetric Synthons. J. Am. Chem. Soc., 2006, 128(27), 8702 - 8703. Click here for online access to article.

Yue, D.; Cá, N. D.; Larock, R. C. Syntheses of Isochromenes and Naphthalenes by Electrophilic Cyclization of Acetylenic Arenecarboxaldehydes. J. Org. Chem. 2006, 71(9), 3381-3388. Click here for online access to article.

Liu, Z.; Larock, R. C. Facile N-Arylation of Amines and Sulfonamides and O-Arylation of Phenols and Arenecarboxylic Acids. J. Org. Chem. 2006, 71(8), 3198-3209. Click here for online access to article.

Peng, W.; Blagg, B. S. J. A Versatile Approach toward the Ansamycin Antibiotics. Org. Lett. 2006, 8(5), 975-978. Click here for online access to article.

Schoenen, F. J.; Aubé, J. Arthur Suite V. 3.0 Symyx Technologies, Inc. (Computer Software Review) J. Am. Chem. Soc., 2006, 128(2), 664-665. Click here for online access to article.

Kesharwani, T.; Worlikar, S. A.; Larock, R. C. Synthesis of 2,3-Disubstituted Benzo[b]selenophenes via Electrophilic Cyclization. J. Org. Chem. 2006, 71(6), 2307-2312. Click here for online access to article.

Zhou, C.; Dubrovsky, A. V.; Larock, R. C. Diversity-Oriented Synthesis of 3-Iodochromones and Heteroatom Analogues via ICl-Induced Cyclization. J. Org. Chem. 2006, 71(4), 1626-1632. Click here for online access to article.

Hershberger, J. C.; Zhang, L.; Lu, G.; Malinakova, H. C. Polymer-Supported Palladacycles: Efficient Reagents for Synthesis of Benzopyrans with Palladium Recovery. Relationship among Resin Loading, Pd:P Ratio, and Reactivity of Immobilized Palladacycles. J. Org. Chem. 2006, 71(1), 231-235. Click here for online access to article.

Yue, D.; Yao, T.; Larock, R. C. Synthesis of 3-Iodoindoles by the Pd/Cu-Catalyzed Coupling of N,N-Dialkyl-2-iodoanilines and Terminal Acetylenes, Followed by Electrophilic Cyclization. J. Org. Chem. 2006, 71(1), 62-69. Click here for online access to article.

2005

Givens, R. S.; Yousef, A. p-Hydroxyphenacyl: A Photoremovable Protecting Group for Caging Bioactive Substrates (Chp. Ic) in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules; J. Wiley, and Sons, 2005; pp 55-75.

Li, K.; Foresee, L. N.; Tunge, J. A. Trifluoroacetic Acid-Mediated Hydroarylation: Synthesis of Dihydrocoumarins and Dihydroquinolones. J. Org. Chem. 2005, 70(7), 2881-2883. Click here for online access to article.

Ramanathan, S. K.; Keeler, J.; Lee, H-L.; Reddy, D. S.; Lushington, G.; Aubé, J. Modular Synthesis of Cyclic Peptidomimetics Inspired by γ-Turns. Org. Lett. 2005, 7(6), 1059-1062. Click here for online access to article.

Mitscher, L. A. Bacterial Topoisomerase Inhibitors: Quinolone and Pyridine Antibacterial Agents. Chem.Rev. 2005, 105(2), 559-592. Click here for online access to article.

Harned, A. M.; Song He, H.; Toy, P. H.; Flynn, D. L.; Hanson, P. R. Multipolymer Solution-Phase Reactions: Application to the Mitsunobu Reaction. J. Am. Chem. Soc. 2005, 127(1), 52-53. Click here for online access to article.

2004

Zhang, M.; Moore, J. D.; Flynn, D. L.; Hanson, P. R. Development of High-Load, Soluble Oligomeric Sulfonate Esters via ROM Polymerization: Application to the Benzylation of Amines. Org. Lett. 2004, 6(16), 2657-2660. Click here for online access to article.

Zhang, M., Vedantham, P.; Flynn, D. L., Hanson, P. R. High-Load, Soluble Oligomeric Carbodiimide: Synthesis and Application in Coupling Reactions. J. Org. Chem. 2004, 69(24), 8340-8344. Click here for online access to article.

Lu, G.; Malinakova, H. C. Regio- and Diastereoselective Insertion of Allenes into Stable Oxapalladacycles with a Metal-Bonded Stereogenic Carbon. Preparation of Contiguously Substituted 3,4-Dihydro-2H-1-Benzopyrans. J. Org. Chem. 2004, 69(24), 8266-8279. Click here for online access to article.

Yue, D.; Larock, R. C. Synthesis of 3-Iodoindoles by Electrophilic Cyclization of N,N-Dialkyl-2-(1-alkynyl)anilines. Org. Lett. 2004, 6(6), 1037-1040. Click here for online access to article.