The mission of the Synthesis Core
is to:
(1) be a resource for Center principal investigators and
their colleagues to validate their novel chemical methodologies,
(2) be a repository for reagents and compound sets produced within
the greater Center, and
(3) be a broker of Center reagents and compounds in the greater
biomedical research community
Personnel
The
Director of the Synthesis Core is Dr.
Frank Schoenen. Dr. Schoenen received his Ph.D. in organic
chemistry with Prof. Steven D. Burke at the University of South
Carolina in 1987. He then did postdoctoral studies as an NIH Fellow
in the laboratories of Prof. Stuart L. Schreiber at Yale University
and Harvard University. Dr. Schoenen joined the pharmaceutical
company Glaxo in 1990 as a medicinal chemist working in the inflammation
therapeutic area, contributed to the early efforts to apply combinatorial
chemistry within GlaxoWellcome as a colleague of H. Mario Geysen,
and worked in Discovery Research High Throughput Chemistry in
the nuclear receptor system in GlaxoSmithKline. He joined the
KU CMLD in July of 2005. Dr. Schoenen is an Associate Research
Professor in the Higuchi Biosciences Center and Courtesy Associate
Professor in the Department of Medicinal Chemistry.
Click
here to send Dr. Schoenen an email.
Mr.
David Hill is a 2007 graduate of the University of Kansas
where he earned the Bachelor of Arts degree in Human Biology.
He is currently working as a Research Assistant/Library
Synthesis Specialist for the Core B after serving in
a similar capacity, part-time, as an undergraduate. David specializes
in the operation of laboratory instrumentation. His automation
expertise includes the Chemspeed SLT100 Automated Synthesizer,
for which he is a Center super-user. David is also an expert user
for a variety of instrumentation from the MT AutoChem Medicinal
Chemistry Toolbox: MiniBlock, MiniMapper, ALLEXis, and Balance
Automator. In addition to validating new chemical methodologies
and producing compound libraries, David contributes to compound
management, from data-management through compound submission to
Center Biological Outreach Partners. In his spare time, David
is studying toward a second degree, in Chemistry, from the University
of Kansas.
Facilities
The CMLD laboratories, which incorporate a mix of traditional synthesis space (eleven 8 ft. hoods and associated benches, offices, etc.) and flexible work space appropriate for library synthesis and purification activities, are fully occupied by a combination of permanent staff as well as postdoctoral associates assigned to specific CMLD projects.
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Core staff members meet in their new office in the Structural
Biology Center. |
The Synthesis Core provides expertise and instruments
for performing solution- and solid-phase chemistry and compound
management. The major equipment located in the Synthesis Core,
which is available to all Center participants, includes:
(1) the Innovative Technology Pure-Solv
(2) the Chemspeed Accelerator SLT 100
for automated chemical synthesis
(3) the MT Autochem MiniBlock, MiniBlock
XT, MiniBlock XT Plus, Radley’s Greenhouse, IRORI Kan system,
and Argonaut Quest 205 and 210 Synthesizers for serial/parallel/semi-automated/manual
solution- and solid-phase synthesis
(4) the Biotage Emrys Optimizer for serial microwave-assisted
synthesis
(5) the Gilson 215 SPE, Teledyne ISCO CombiFlash
Companion and Biotage Horizon purification systems
(6) the Genevac EZ-2 Plus and Genevac DD-4
for parallel solvent evaporation
(7) the VirTis AdVantage Freeze Dryer
for batch freeze drying
(8) the MT AutoChem ALLEXis for automated
liquid-liquid extraction
(9) the MT AutoChem MiniMapper for automated
liquid-handling
(10) the Innovative Technology System One
Glovebox
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Dr. Kevin Frankowski syringes solvent purified using the Innovative Technology, Inc. Pure-Solv SPS-400-5 solvent purification system. For additional information, please visit www.innovativet.com/solvent-purification.htm
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The Chemspeed Accelerator SLT100 performs fully-automated liquid- and solid-handling, reaction agitation/heating/cooling, liquid-liquid extraction, solid-phase extraction, and solvent evaporation. For additional information, please visit www.chemspeed.com/index.php
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Dr. Kelin Li employs the MiniBlock for solution-phase synthesis using solid-phase reagents and scavengers to facilitate the synthesis of libraries of dihydrocoumarin and coumarin compounds. For additional information, please visit www.mt.com/autochem
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| Flash Chromatography: ISCO CombiFlash Companion | |
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Dr. Partha Ghosh uses the CombiFlash Companion flash chromatography system to purify library building blocks. For additional information, please visit www.isco.com
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Ms. Julica Nöth uses the Genevac EZ-2 Plus to remove solvent from compounds in vials destined for Center biological outreach partners. For additional information, please visit www.genevac.com
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| Batch Freeze Drying: VirTis AdVantage Freeze Dryer | |
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Dr. Thomas Coombs uses the VirTis AdVantage Freeze Dryer to prepare his compound samples for submission to biological partners. For additional information, please visit http://www.virtis.com
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| Liquid-Liquid Extraction: MT AutoChem ALLEXis | |
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Dr. Erik Fenster uses the MT AutoChem ALLEXis to perform automated liquid-liquid extractions. For additional information, please visit www.mt.com/autochem
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Dr. Thomas Coombs assists Ms. Tatiana Odintsova as they program the MT Autochem MiniMapper to perform liquid-handling for the MiniBlock XT. For additional information, please visit www.mt.com/autochem
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| Environment Control: Innovative Technology System One Glovebox | |
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Dr. Kelin Li uses the Innovative Technology System One Glovebox to weigh an air-sensitive reaction catalyst. For additional information, please visit http://www.innovativet.com/glove-box-systems.htm
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